Characters

Main Protagonists: Main Antagonists:
 * Shido Tatsuhiko: A vampire who appears to be in his mid-twenties with lavender hair. Despite appearances, he's centuries old and has no real memories of his human life before Cain turned him into a vampire. He owns a detective agency that hunts nightbreeds, and he's dedicated to protecting humans against inhuman threats (the nightbreeds).
 * Riho Yamazaki: An orphan teenage girl whose family were killed by nightbreeds. She now works as Shido's secretary. She's infatuated with him and tries to win his affections but gets jealous when Yayoi always seems closer to Shido. In Episode 4, The Golden Dawn, Shido sires her into a vampire after Cain fatally injures her.
 * Yayoi Matsunaga: A human woman from the NOS-agency who brings Shido nightbreed related cases and also acts as a donor, letting him drink her blood for sustenance. Yayoi is very flirtatious and seems quite close to Shido. She carries a gun loaded with silver-coated bullets with her at all times and is a woman of action.
 * Guni: A small green urban fairy that hides in people's hair, preferably Shido's. She's usually sarcastic and loves to bicker with Riho and Yayoi, but is shown to really care for them. Although she mostly serves as comic relief for the show she does possess some magical powers and has aided Shido in battle.
 * Cain: An ancient vampire with tremendous power who sired Shido into a vampire. Shido used to live with Cain, but was driven away by Cain's arrogance, possessiveness, and cruelty. He came from Transylvania to witness The Golden Dawn. Despite Shido leaving him, he still cares for his fledgling and wants Shido to come back to him. He fatally injured Riho forcing Shido to turn her into a vampire to save her.
 * Various Nightbreeds: The nightbreeds are creatures that dwell in darkness and posses human bodies so they can live in the light. Normally they possess people who are brain dead or have recently died, but can also possess a living human if the human forms a contract with them. They have a strong desire for human flesh and appear to enjoy causing humans distress and anguish.
 * Various Vampires: Vampires are former humans that have gained immortality. the ability to manipulate their blood to form weapons, and other abilities such as telekinesis and greatly enhanced speed, strength, and regeneration. They have a strong desire for human blood.